In the ninth annual Disruptor 50 list, CNBC highlights the private companies leading out of the pandemic with business models and growth rates aligned with a rapid pace of technological change. 

Investors have taken notice that the companies on the 2021 Disruptor 50 list have become critical players in fundamental economic and consumer transformations. A majority of the CNBC Disruptor 50 are already billion-dollar businesses. Thirty-four disruptors are unicorns that have already reached or passed (in some cases far surpassed) the $1 billion valuation mark — 10 of the companies on this year’s list are worth at least $10 billion. 

The 50 companies selected using the proprietary Disruptor 50 methodology have raised over $72 billion in venture capital, according to PitchBook, at an implied Disruptor 50 valuation of more than $388 billion. While technologies including AI, 5G, cloud computing and the Internet of Things are key to many companies making the 2021 Disruptor 50 list, the sectors they are upending are widespread, from financial services to health care, biotech, education, food, media, agriculture and transportation.

1 Robinhood Wall Street’s frenemy
2 Stripe The GDP of the Internet
3 Discord The Internet chat room, re-imagined
4 SentinelOne A SolarWinds saving grace
5 Didi Chuxing Your $100 billion IPO is on the way
6 Brex Giving credit to the start-up economy
7 Marqeta Playing their cards right
8 Chime Software as a bank
9 TytoCare Urgent care delivered virtually
10 ElevateBio Building a deep lab bench
11 K Health The health care app will see you now
12 Convoy Freight’s neural network
13 Checkout.com Transactional relationships
14 Indigo Ag Top soil
15 Snyk Sniffing out open-source flaws
16 Tempus Informing the precision clinician
17 Lineage Logistics Cold comfort
18 Gojek Southeast Asia’s super-app
19 CLEAR Keep the line moving
20 TALA The underserved deserve credit
21 Flutterwave Helping Africa’s small business soar
22 Thrasio Transforming the Amazon economy
23 Relativity Space Engineering an interplanetary future
24 Impossible Foods Beyond possible
25 AMP Robotics Robots recycle better
26 Neteera A sixth sense in medicine
27 Cockroach Labs Deep inside enterprise cloud data
28 Cityblock Health Because everyone deserves good health care
29 Udacity Graduating a new generation of skilled labor
30 Apeel Good preservatives
31 Sight Diagnostics See the whole picture in two drops of blood
32 Cybereason Fighting the dark side
33 Clubhouse The new sound of social
34 Sila Nanotechnologies Making EV batteries better is no small thing
35 Bestow Digital transformation comes to life (insurance)
36 Gopuff When you need stuff ASAP
37 Databricks The next Snowflake?
38 Ripple Making waves in crypto regulation
39 Plaid The gateway to Venmo, Robinhood, Coinbase
40 Nubank Latin America’s big bank challenger
41 Flexport Supply chain economics
42 Flock Freight Carbon-smart truckloads
43 Eat JUST The egg and the chicken
44 Movandi Making 5G a broader reality
45 Footprint Just three words for you: No more plastic
46 Airtable Code for non-coders
47 BlocPower Fighting climate change block-by-block
48 Patreon How the creative class gets paid
49 Guild Education Education as a benefit
50 Heal New ideas in home-based health care
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